KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis.

Fang TianJinzhi ZhaoShaochong BuHe TengJun YangXiaomin ZhangXiaorong LiJuping Liu

Published in: Drug design, development and therapy (2020)

The ATF4-ATF3-CHOP pathway plays an important role in KLF6-induced apoptosis in HLECs. Our results increase our understanding of the mechanisms that regulate LEC apoptosis and contribute to the development of a new preventative strategy for cataract.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
transcription factor
diffuse large b cell lymphoma
endothelial cells
oxidative stress
signaling pathway
cell death
induced pluripotent stem cells
pluripotent stem cells
cataract surgery