Long non-coding RNAs in ovarian granulosa cells.
Jiajie TuYu ChenZhe LiHuan YangHe ChenZhi-Ying YuPublished in: Journal of ovarian research (2020)
Granulosa cells (GCs) are somatic cells surrounding oocytes within follicles and are essential for folliculogenesis. Pathological changes in GCs are found in several ovarian disorders. Recent reports have indicated that long non-coding RNAs (lncRNAs), which modulate gene expression via multiple mechanisms, are key regulators of the normal development of GCs, follicles, and ovaries. In addition, accumulating evidence has suggested that lncRNAs can be utilized as biomarkers for the diagnosis and prognosis of GC-related diseases, such as polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). Therefore, lncRNAs not only play a role in GCs that are involved in normal folliculogenesis, but they may also be considered as potential candidate biomarkers and therapeutic targets in GCs under pathological conditions. In the future, a detailed investigation of the in vivo delivery or targeting of lncRNAs and large-cohort-validation of the clinical applicability of lncRNAs is required.
Keyphrases
- polycystic ovary syndrome
- long non coding rna
- induced apoptosis
- gene expression
- cell cycle arrest
- poor prognosis
- insulin resistance
- network analysis
- endoplasmic reticulum stress
- emergency department
- transcription factor
- oxidative stress
- genome wide analysis
- genome wide identification
- type diabetes
- adipose tissue
- signaling pathway
- mass spectrometry
- genome wide
- electronic health record
- metabolic syndrome
- liquid chromatography