INHALEd nebulised unfractionated HEParin for the treatment of hospitalised patients with COVID-19 (INHALE-HEP): Protocol and statistical analysis plan for an investigator-initiated international metatrial of randomised studies.
Frank M P van HarenAlice RichardsonHwan-Jin YoonAntonio ArtigasJohn G LaffeyBarry DixonRoger SmithAlicia B VilasecaRuben A BarberaTarek I IsmailRabab S MahrousMohamed BadrGilberto De NucciCarlos SverdloffLex M van LoonMarta Camprubi-RimblasDavid W CosgraveThomas L SmootSabrina StaasKhine SannCaitlin SasAnusha BelaniChristopher HillmanJanis ShuteMary CarrollTom WilkinsonMiles CarrollDave SinghClive PagePublished in: British journal of clinical pharmacology (2021)
The metatrial is registered at ClinicalTrials.gov ID NCT04635241. Each contributing study is individually registered and has received approval of the relevant ethics committee or institutional review board. Results of this study will be shared with the World Health Organisation, published in scientific journals and presented at scientific meetings.