Renal mineralocorticoid receptor expression is reduced in lipoatrophy.
Barbara ToffoliStella BernardiCarine WinklerCoralie CarrascosaFederica GilardiBéatrice DesvergnePublished in: FEBS open bio (2019)
Obesity is a condition characterized by adipose tissue hypertrophy; it is estimated that the obesity epidemic accounted for 4 million deaths in 2015 and that 70% of these were due to cardiovascular disease (CVD). One of the mechanisms linking obesity to CVD is the ability of adipose tissue to secrete circulating factors. We hypothesized that adipose tissue and its secretory products may influence mineralocorticoid receptor (MR) expression. Here, we showed that expression of MR and its downstream targets (Cnksr3, Scnn1b, and Sgk1) were significantly reduced in the kidneys of peroxisome proliferator-activated receptor-γ null (Pparg Δ/Δ ) and A-ZIP/F-1 (AZIPtg/+) lipoatrophic mice with respect to their controls. Intriguingly, MR expression was also found to be significantly reduced in the kidneys of genetically obese ob/ob mice. Our data suggest that adipose tissue contributes to the regulation of MR expression. Given that leptin deficiency seems to be the major feature shared by Pparg Δ/Δ , AZIPtg/+, and ob/ob mice, we speculate that adipose tissue modulates MR expression through the leptin system.
Keyphrases
- adipose tissue
- insulin resistance
- high fat diet induced
- poor prognosis
- metabolic syndrome
- cardiovascular disease
- high fat diet
- type diabetes
- weight loss
- binding protein
- magnetic resonance
- contrast enhanced
- long non coding rna
- machine learning
- coronary artery disease
- bariatric surgery
- computed tomography
- physical activity
- electronic health record
- skeletal muscle
- cardiovascular events