Assessment of immunological anti-platelet factor 4 antibodies for vaccine-induced thrombotic thrombocytopenia (VITT) in a large Australian cohort: A multicenter study comprising 1284 patients.

Emmanuel J Favaloro Joanne Clifford Emma Leitinger Michael Parker Pauline Sung Sanjeev Daya Chunilal Huyen A Tran Geoffrey W Kershaw Suki Fu Freda H Passam Monica Ahuja Shir Jing Ho Elizabeth Duncan Olivia Yacoub Chee Wee Tan Lisa Kaminskis Natasha Modica Dominic Pepperell Leanne Ballard Lisa Clarke Christine Shu Mei Lee Elizabeth E Gardiner Philip Young-Ill Choi Ibrahim Tohidi-Esfahani Robert J Bird Timothy Brighton Vivien M Y Chen

Published in: Journal of thrombosis and haemostasis : JTH (2022)

To our knowledge, this is the largest multicenter evaluation of anti-PF4 testing for investigation of VITT. Discrepancies in test results (ELISA vs. ELISA or ELISA vs. functional assay) in some patients highlighted limitations in relying on single methods (ELISA and functional) for PF4 antibody detection in VITT, and also highlights the variability in phenotypic test presentation and pathomechanism of VITT.

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