Gibbs free energy of protein-protein interactions correlates with ATP production in cancer cells.
Stefan M GolasAmber N NguyenEdward A RietmanJack Adam TuszynskiPublished in: Journal of biological physics (2019)
In this paper, we analyze several cancer cell types from two seemingly independent angles: (a) the over-expression of various proteins participating in protein-protein interaction networks and (b) a metabolic shift from oxidative phosphorylation to glycolysis. We use large data sets to obtain a thermodynamic measure of the protein-protein interaction network, namely the associated Gibbs free energy. We find a strong inverse correlation between the percentage of energy production via oxidative phosphorylation and the Gibbs free energy of the protein networks. The latter is a measure of functional dysregulation within the cell. Our findings corroborate earlier indications that signaling pathway upregulation in cancer cells is linked to the metabolic shift known as the Warburg effect; hence, these two seemingly independent characteristics of cancer phenotype may be interconnected.
Keyphrases
- protein protein
- small molecule
- signaling pathway
- poor prognosis
- papillary thyroid
- protein kinase
- pi k akt
- single cell
- cell proliferation
- squamous cell
- cell therapy
- epithelial mesenchymal transition
- long non coding rna
- electronic health record
- stem cells
- binding protein
- induced apoptosis
- oxidative stress
- young adults
- deep learning
- artificial intelligence
- data analysis