Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer.
Biagio RicciutiJieun SonJeffrey J OkoroAlessia MiraEnrico PatruccoYoonji EumXinan WangRaymond ParanalHaiyun WangMika LinHeidi M HaikalaJiaqi LiYue XuJoao M Victor AlessiChhayheng ChhoeuAmanda J RedigJens KöhlerKshiti H DholakiaYunhan ChenElodie RichardMarie-Julie NokinDavid SantamariaPrafulla C GokhaleMark M AwadPasi A JanneChiara AmbrogioPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
This study demonstrates that KRAS isoforms are highly heterogeneous in terms of concurrent genomic alterations and gene-expression profiles, and that stratification based on KRAS alleles should be considered in the design of future clinical trials.