Pasi A Janne (Pasi A Ja Nne, Pasi A Jänne)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 58

Top Topics

Tyrosine Kinase

Epidermal Growth Factor Receptor

Top Venues

Cancer discovery

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Nature reviews. Clinical oncology

JCO precision oncology

This page only lists publications with an associated author ORCID identifier.

Publications

Jaclyn LoPiccolo, Alexander Gusev, David C Christiani, Pasi A Janne
Lung cancer in patients who have never smoked - an emerging disease. Nature reviews. Clinical oncology 21 (2) (2024)
Rona Yaeger, Nataliya V Uboha, Meredith S Pelster, Tanios S Bekaii-Saab, Minal Barve, Joel Saltzman, Joshua K Sabari, Julio Antonio Peguero, Andrew Scott Paulson, Pasi A Janne, Marcia Roxana Cruz-Correa, Kenna Anderes, Karen Velastegui, Xiaohong Yan, Hirak Der-Torossian, Samuel J Klempner, Edmund S Kopetz
Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer. Cancer discovery (2024)
Pasi A Janne, David Planchard, Kunihiko Kobayashi, James Chih-Hsin Yang
Reply to Y. Yu et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (17) (2024)
Ezra Bernstein, Jia Luo, Kaiwen Wang, Marcelo Vailati Negrão, Pasi A Janne, Joshua K Sabari
Safety and Intracranial Activity of Adagrasib in Patients With KRAS G12C -Mutated Non-Small-Cell Lung Cancer and Untreated CNS Metastases in the KRYSTAL-1 Trial: A Case Series. JCO precision oncology 8 (2024)
Jaclyn LoPiccolo, Alexander Gusev, David C Christiani, Pasi A Janne
Lung cancer in patients who have never smoked - an emerging disease. Nature reviews. Clinical oncology 21 (2) (2024)
Federica Pecci, Seshiru Nakazawa, Biagio Ricciuti, Guilherme Harada, Jessica K Lee, Joao M Victor Alessi, Adriana P Barrichello, Victor R Vaz, Giuseppe Lamberti, Alessandro Di Federico, Malini M Gandhi, Dimitrios Gazgalis, William W Feng, Jie Jiang, Simon Baldacci, Marie-Anaïs Locquet, Felix H Gottlieb, Monica F Chen, Elinton Lee, Danielle Haradon, Anna Smokovich, Emma Voligny, Tom Nguyen, Vikas K Goel, Zachary Zimmerman, Sumandeep Atwal, Xinan Wang, Magda Bahcall, Rebecca S Heist, Sumaiya Iqbal, Nishant Gandhi, Andrew Elliott, Ari M VanderWalde, Patrick C Ma, Balazs Halmos, Stephen V Liu, Jianwei Che, Alexa B Schrock, Alexander E Drilon, Pasi A Janne, Mark M Awad
Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors. Cancer discovery (2024)
Ezra Bernstein, Jia Luo, Kaiwen Wang, Marcelo Vailati Negrão, Pasi A Janne, Joshua K Sabari
Safety and Intracranial Activity of Adagrasib in Patients With KRAS G12C -Mutated Non-Small-Cell Lung Cancer and Untreated CNS Metastases in the KRYSTAL-1 Trial: A Case Series. JCO precision oncology 8 (2024)
Pasi A Janne, David Planchard, Kunihiko Kobayashi, James Chih-Hsin Yang
Reply to Y. Yu et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Rona Yaeger, Nataliya V Uboha, Meredith S Pelster, Tanios S Bekaii-Saab, Minal Barve, Joel Saltzman, Joshua K Sabari, Julio Antonio Peguero, Andrew Scott Paulson, Pasi A Janne, Marcia Roxana Cruz-Correa, Kenna Anderes, Karen Velastegui, Xiaohong Yan, Hirak Der-Torossian, Samuel J Klempner, Edmund S Kopetz
Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer. Cancer discovery 14 (6) (2024)
Rona Yaeger, Nataliya V Uboha, Meredith S Pelster, Tanios S Bekaii-Saab, Minal Barve, Joel Saltzman, Joshua K Sabari, Julio Antonio Peguero, Andrew Scott Paulson, Pasi A Janne, Marcia Roxana Cruz-Correa, Kenna Anderes, Karen Velastegui, Xiaohong Yan, Hirak Der-Torossian, Samuel J Klempner, Edmund S Kopetz
Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer. Cancer discovery 14 (6) (2024)
Jaclyn LoPiccolo, Alexander Gusev, David C Christiani, Pasi A Janne
Lung cancer in patients who have never smoked - an emerging disease. Nature reviews. Clinical oncology 21 (2) (2024)
Rona Yaeger, Nataliya V Uboha, Meredith S Pelster, Tanios S Bekaii-Saab, Minal Barve, Joel Saltzman, Joshua K Sabari, Julio Antonio Peguero, Andrew Scott Paulson, Pasi A Janne, Marcia Roxana Cruz-Correa, Kenna Anderes, Karen Velastegui, Xiaohong Yan, Hirak Der-Torossian, Samuel J Klempner, Edmund S Kopetz
Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer. Cancer discovery 14 (6) (2024)
Jaclyn LoPiccolo, Alexander Gusev, David C Christiani, Pasi A Janne
Lung cancer in patients who have never smoked - an emerging disease. Nature reviews. Clinical oncology (2024)
Rona Yaeger, Nataliya V Uboha, Meredith S Pelster, Tanios S Bekaii-Saab, Minal Barve, Joel Saltzman, Joshua K Sabari, Julio Antonio Peguero, Andrew Scott Paulson, Pasi A Janne, Marcia Roxana Cruz-Correa, Kenna Anderes, Karen Velastegui, Xiaohong Yan, Hirak Der-Torossian, Samuel J Klempner, Edmund S Kopetz
Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer. Cancer discovery 14 (6) (2024)
Federica Pecci, Seshiru Nakazawa, Biagio Ricciuti, Guilherme Harada, Jessica K Lee, Joao M Victor Alessi, Adriana P Barrichello, Victor R Vaz, Giuseppe Lamberti, Alessandro Di Federico, Malini M Gandhi, Dimitrios Gazgalis, William W Feng, Jie Jiang, Simon Baldacci, Marie-Anaïs Locquet, Felix H Gottlieb, Monica F Chen, Elinton Lee, Danielle Haradon, Anna Smokovich, Emma Voligny, Tom Nguyen, Vikas K Goel, Zachary Zimmerman, Sumandeep Atwal, Xinan Wang, Magda Bahcall, Rebecca S Heist, Sumaiya Iqbal, Nishant Gandhi, Andrew Elliott, Ari M VanderWalde, Patrick C Ma, Balazs Halmos, Stephen V Liu, Jianwei Che, Alexa B Schrock, Alexander E Drilon, Pasi A Janne, Mark M Awad
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors. Cancer discovery 14 (8) (2024)
Jaclyn LoPiccolo, Alexander Gusev, David C Christiani, Pasi A Janne
Lung cancer in patients who have never smoked - an emerging disease. Nature reviews. Clinical oncology 21 (2) (2024)
Jaclyn LoPiccolo, Alexander Gusev, David C Christiani, Pasi A Janne
Lung cancer in patients who have never smoked - an emerging disease. Nature reviews. Clinical oncology 21 (2) (2024)
Pasi A Janne, David Planchard, Kunihiko Kobayashi, James Chih-Hsin Yang
Reply to Y. Yu et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42 (17) (2024)
Federica Pecci, Seshiru Nakazawa, Biagio Ricciuti, Guilherme Harada, Jessica K Lee, Joao M Victor Alessi, Adriana P Barrichello, Victor R Vaz, Giuseppe Lamberti, Alessandro Di Federico, Malini M Gandhi, Dimitrios Gazgalis, William W Feng, Jie Jiang, Simon Baldacci, Marie-Anaïs Locquet, Felix H Gottlieb, Monica F Chen, Elinton Lee, Danielle Haradon, Anna Smokovich, Emma Voligny, Tom Nguyen, Vikas K Goel, Zachary Zimmerman, Sumandeep Atwal, Xinan Wang, Magda Bahcall, Rebecca S Heist, Sumaiya Iqbal, Nishant Gandhi, Andrew Elliott, Ari M VanderWalde, Patrick C Ma, Balazs Halmos, Stephen V Liu, Jianwei Che, Alexa B Schrock, Alexander E Drilon, Pasi A Janne, Mark M Awad
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors. Cancer discovery 14 (8) (2024)
Jaclyn LoPiccolo, Alexander Gusev, David C Christiani, Pasi A Janne
Lung cancer in patients who have never smoked - an emerging disease. Nature reviews. Clinical oncology 21 (2) (2024)
Federica Pecci, Seshiru Nakazawa, Biagio Ricciuti, Guilherme Harada, Jessica K Lee, Joao M Victor Alessi, Adriana P Barrichello, Victor R Vaz, Giuseppe Lamberti, Alessandro Di Federico, Malini M Gandhi, Dimitrios Gazgalis, William W Feng, Jie Jiang, Simon Baldacci, Marie-Anaïs Locquet, Felix H Gottlieb, Monica F Chen, Elinton Lee, Danielle Haradon, Anna Smokovich, Emma Voligny, Tom Nguyen, Vikas K Goel, Zachary Zimmerman, Sumandeep Atwal, Xinan Wang, Magda Bahcall, Rebecca S Heist, Sumaiya Iqbal, Nishant Gandhi, Andrew Elliott, Ari M VanderWalde, Patrick C Ma, Balazs Halmos, Stephen V Liu, Jianwei Che, Alexa B Schrock, Alexander E Drilon, Pasi A Janne, Mark M Awad
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors. Cancer discovery 14 (8) (2024)
Helena A Yu, James Chih-Hsin Yang, Hidetoshi Hayashi, Yasushi Goto, Enriqueta Felip, Martin Reck, Michele Vigliotti, Qian Dong, Frédérique Cantero, Pang-Dian Fan, Masayuki Kanai, David W Sternberg, Pasi A Janne
HERTHENA-Lung01: a phase II study of patritumab deruxtecan (HER3-DXd) in previously treated metastatic EGFR -mutated NSCLC. Future oncology (London, England) (2023)
Geoffrey R Oxnard, Ruthia Chen, Jennifer C Pharr, Diane R Koeller, Arrien A Bertram, Suzanne E Dahlberg, Irene R Rainville, Kate P Shane-Carson, Kelly A Taylor, Alicia Sable-Hunt, Lynette M Sholl, Craig C Teerlink, Alun Thomas, Lisa Anne Cannon-Albright, André P Fay, Patricia Ashton-Prolla, Hao Yang, Mary M Salvatore, Bonnie J Addario, Pasi A Janne, David P Carbone, Georgia L Wiesner, Judy E Garber
Germline EGFR mutations and familial lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Antonio Passaro, Pasi A Janne, Solange Peters
Antibody-Drug Conjugates in Lung Cancer: Recent Advances and Implementing Strategies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Michael L Cheng, Yeying Huang, Nhi Luong, Jaclyn LoPiccolo, Mizuki Nishino, Lynette M Sholl, Lucian R Chirieac, Alison D Santucci, Michael S Rabin, Pasi A Janne, Shodeinde Coker, Jennifer R Diamond, John Hilton, Geoffrey I Shapiro, Christopher A French
Exceptional Response to Bromodomain and Extraterminal Domain Inhibitor Therapy With BMS-986158 in BRD4-NUTM1 NUT Carcinoma Harboring a BRD4 Splice Site Mutation. JCO precision oncology 7 (2023)
Lars D Engstrom, Ruth Aranda, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, David Trinh, Allan Hebbert, Christopher R Smith, Svitlana Kulyk, J David Lawson, Quanyuan He, Laura D Hover, Julio Fernandez-Banet, Jill Hallin, Darin Vanderpool, David M Briere, Alice Blaj, Matthew A Marx, Jordi Rodon Ahnert, Michael D Offin, Kathryn C Arbour, Melissa Lynne Johnson, David J Kwiatkowski, Pasi A Janne, Candace L Haddox, Kyriakos P Papadopoulos, Jason T Henry, Konstantinos Leventakos, James G Christensen, Ronald Shazer, Peter Olson
MRTX1719 is an MTA-cooperative PRMT5 inhibitor that exhibits synthetic lethality in preclinical models and patients with MTAP deleted cancer. Cancer discovery (2023)
Helena Alexandra Yu, Yasushi Goto, Hidetoshi Hayashi, Enriqueta Felip Font, James Chih-Hsin Yang, Martin Reck, Kiyotaka Yoh, Se-Hoon Lee, Luis G Paz-Ares, Benjamin Besse, Paolo Bironzo, Dong Wan Kim, Melissa Lynne Johnson, Yi-Long Wu, Thomas John, Steven Kao, Toshiyuki Kozuki, Erminia Massarelli, Jyoti D Patel, Egbert F Smit, Karen L Reckamp, Qian Dong, Pomy Shrestha, Pang-Dian Fan, Parul Patel, Andrea Sporchia, David W Sternberg, Dalila Sellami, Pasi A Janne
HERTHENA-Lung01, a Phase II Trial of Patritumab Deruxtecan (HER3-DXd) in Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Platinum-Based Chemotherapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Tony S K Mok, Pasi A Janne, Makoto Nishio, Silvia Novello, Martin Reck, Conor E Steuer, Yi-Long Wu, Ronan Fougeray, Pang-Dian Fan, Jie Meng, David W Sternberg, Stephen Esker, Helena Alexandra Yu
HERTHENA-Lung02: phase III study of patritumab deruxtecan in advanced EGFR -mutated NSCLC after a third-generation EGFR TKI. Future oncology (London, England) (2023)
Koichi Goto, Yasushi Goto, Toshio Kubo, Kiichiro Ninomiya, Sang-We Kim, David Planchard, Myung-Ju Ahn, Egbert F Smit, Adrianus Johannes de Langen, Maurice Pérol, Elvire Pons-Tostivint, Silvia Novello, Hidetoshi Hayashi, Junichi Shimizu, Dong Wan Kim, Chih-Hsi Kuo, James Chih-Hsin Yang, Kaline Pereira, Fu-Chih Cheng, Ayumi Taguchi, Yingkai Cheng, Wenqin Feng, Zenta Tsuchihashi, Pasi A Janne
Trastuzumab Deruxtecan in Patients With HER2 -Mutant Metastatic Non-Small-Cell Lung Cancer: Primary Results From the Randomized, Phase II DESTINY-Lung02 Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Arvind Ravi, Matthew D Hellmann, Monica B Arniella, Mark Holton, Samuel S Freeman, Vivek Naranbhai, Chip Stewart, Ignaty Leshchiner, Jaegil Kim, Yo Akiyama, Aaron T Griffin, Natalie I Vokes, Mustafa Sakhi, Vashine Kamesan, Hira Rizvi, Biagio Ricciuti, Patrick M Forde, Valsamo Anagnostou, Jonathan W Riess, Don L Gibbons, Nathan A Pennell, Vamsidhar Velcheti, Subba R Digumarthy, Mari A Mino-Kenudson, Andrea Califano, John Victor Heymach, Roy S Herbst, Julie R Brahmer, Kurt A Schalper, Victor E Velculescu, Brian S Henick, Naiyer Rizvi, Pasi A Janne, Mark M Awad, Andrew Chow, Benjamin D Greenbaum, Marta Luksza, Alice T Shaw, Jedd D Wolchok, Nir Hacohen, Gad A Getz, Justin F Gainor
Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer. Nature genetics (2023)
Marcelo Vailati Negrão, Alexander I Spira, Rebecca S Heist, Pasi A Janne, Jose M Pacheco, Jared Weiss, Shirish M Gadgeel, Karen Velastegui, Wenjing Yang, Hirak Der-Torossian, James G Christensen, Joshua K Sabari
Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With KRAS G12C -Mutated Non-Small-Cell Lung Cancer Who Have Untreated CNS Metastases. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Biagio Ricciuti, Arielle Elkrief, Joao M Victor Alessi, Xinan Wang, Yvonne Y Li, Hersh V Gupta, Daniel M Muldoon, Arrien A Bertram, Federica Pecci, Giuseppe Lamberti, Alessandro Di Federico, Adriana P Barrichello, Victor R Vaz, Malini M Gandhi, Elinton Lee, Geoffrey I Shapiro, Hyesun Park, Mizuki Nishino, James R Lindsay, Kristen D Felt, Bijaya Sharma, Andrew D Cherniak, Scott J Rodig, Daniel R Gomez, Narek Shaverdian, Mehrdad Rakaee, Chaitanya Bandlamudi, Marc Ladanyi, Pasi A Janne, Adam J Schoenfeld, Lynette M Sholl, Mark M Awad, Michael L Cheng
Clinicopathologic, genomic, and immunophenotypic landscape of ATM mutations in non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Pasi A Janne, David Planchard, Kunihiko Kobayashi, Ying Cheng, Chee Khoon Lee, Natalia Valdivieso, Konstantin Laktionov, Tsung-Ying Yang, Yan Yu, Terufumi Kato, Liyan Jiang, Busayamas Chewaskulyong, Sarayut L Geater, Jean-Marc Maurel, Carlos Rojas, Toshiaki Takahashi, Libor Havel, Frances A Shepherd, Kentaro Tanaka, Dana Ghiorghiu, Neha P Amin, Elena Armenteros-Monterroso, Xiangning Huang, Ammar Ahmed Chaudhry, James Chih-Hsin Yang
CNS Efficacy of Osimertinib With or Without Chemotherapy in Epidermal Growth Factor Receptor-Mutated Advanced Non-Small-Cell Lung Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Cloud P Paweletz, Grace A Heavey, Yanan Kuang, Emily Durlacher, Thian Kheoh, Richard C Chao, Alexander I Spira, Konstantinos Leventakos, Melissa Lynne Johnson, Sai-Hong Ignatius Ou, Gregory J Riely, Kenna Anderes, Wenjing Yang, James G Christensen, Pasi A Janne
Early changes in circulating cell free KRAS G12C predicts response to adagrasib in KRAS mutant non-small cell lung cancer patients. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Yoshihisa Kobayashi, Chhayheng Chhoeu, Jiaqi Li, Kristin S Price, Lesli A Kiedrowski, Jamie L Hutchins, Aaron I Hardin, Zihan Wei, Fangxin Hong, Magda Bahcall, Prafulla C Gokhale, Pasi A Janne
Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers. Nature 603 (7900) (2022)
James Chih-Hsin Yang, Yuichiro Ohe, Chao-Hua Chiu, Xiaoling Ou, Mireille Cantarini, Pasi A Janne, Ryan J Hartmaier, Myung-Ju Ahn
Osimertinib plus selumetinib in EGFR-mutated, non-small cell lung cancer after progression on EGFR-TKIs: A Phase 1b, open-label, multicenter trial (TATTON Part B). Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
James Chih-Hsin Yang, Yuichiro Ohe, Chao-Hua Chiu, Xiaoling Ou, Mireille Cantarini, Pasi A Janne, Ryan J Hartmaier, Myung-Ju Ahn
Osimertinib plus Selumetinib in EGFR-Mutated Non-Small Cell Lung Cancer After Progression on EGFR-TKIs: A Phase Ib, Open-Label, Multicenter Trial (TATTON Part B). Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Ciric To, Tyler S Beyett, Jaebong Jang, William W Feng, Magda Bahcall, Heidi M Haikala, Bo H Shin, David E Heppner, Jaimin K Rana, Brittaney A Leeper, Kara M Soroko, Michael J Poitras, Prafulla C Gokhale, Yoshihisa Kobayashi, Kamal Wahid, Kari J Kurppa, Thomas W Gero, Michael D Cameron, Atsuko Ogino, Mierzhati Mushajiang, Chunxiao Xu, Yanxi Zhang, David A Scott, Michael J Eck, Nathanael S Gray, Pasi A Janne
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nature cancer 3 (4) (2022)
Ryan J Hartmaier, Aleksandra A Markovets, Myung-Ju Ahn, Lecia V Sequist, Ji-Youn Han, Byoung Chul Cho, Helena Alexandra Yu, Sang-We Kim, James Chih-Hsin Yang, Jong Seok Lee, Wu-Chou Su, Dariusz Mirosław Kowalski, Sergey V Orlov, Song Ren, Paul Frewer, Xiaoling Ou, Darren Ae Cross, Nisha Kurian, Mireille Cantarini, Pasi A Janne
Osimertinib+Savolitinib to Overcome Acquired MET-Mediated Resistance in Epidermal Growth Factor Receptor Mutated MET-Amplified Non-Small Cell Lung Cancer: TATTON. Cancer discovery (2022)
Ryohei Yoshida, Maria Saigí, Tetsuo Tani, Benjamin F Springer, Hirofumi Shibata, Shunsuke Kitajima, Navin R Mahadevan, Marco Campisi, Jong Wook Kim, Yoshihisa Kobayashi, Tran C Thai, Koji Haratani, Yurie Yamamoto, Shriram K Sundararaman, Erik H Knelson, Amir Vajdi, Israel Cañadas, Ravindra Uppaluri, Cloud P Paweletz, Juan J Miret, Patrick H Lizotte, Prafulla C Gokhale, Pasi A Janne, David A Barbie
MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer. Cancer research 82 (21) (2022)
Biagio Ricciuti, Jieun Son, Jeffrey J Okoro, Alessia Mira, Enrico Patrucco, Yoonji Eum, Xinan Wang, Raymond Paranal, Haiyun Wang, Mika Lin, Heidi M Haikala, Jiaqi Li, Yue Xu, Joao M Victor Alessi, Chhayheng Chhoeu, Amanda J Redig, Jens Köhler, Kshiti H Dholakia, Yunhan Chen, Elodie Richard, Marie-Julie Nokin, David Santamaria, Prafulla C Gokhale, Mark M Awad, Pasi A Janne, Chiara Ambrogio
Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (8) (2022)
Jieun Son, Jaebong Jang, Tyler S Beyett, Yoonji Eum, Heidi M Haikala, Alyssa L Verano, Mika Lin, John M Hatcher, Nicholas P Kwiatkowski, Pınar Özden Eser, Michael J Poitras, Stephen Wang, Man Xu, Prafulla C Gokhale, Michael D Cameron, Michael J Eck, Nathanael S Gray, Pasi A Janne
A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer. Cancer research 82 (8) (2022)
Mengzhao Wang, James Chih-Hsin Yang, Paul L Mitchell, Jian Fang, D Ross Camidge, Weiqi Nian, Chao-Hua Chiu, Jianying Zhou, Yanqiu Zhao, Wu-Chou Su, Tsung-Ying Yang, Viola W Zhu, Michael Millward, Yun Fan, Wen-Tsung Huang, Ying Cheng, Liyan Jiang, Daniel Brungs, Lyudmila Bazhenova, Chee Khoon Lee, Bo Gao, Yan Xu, Wei-Hsun Hsu, Li Zheng, Pasi A Janne
Sunvozertinib, a Selective EGFR Inhibitor for Previously Treated Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations. Cancer discovery 12 (7) (2022)
Erik H Knelson, Elena V Ivanova, Mubin Tarannum, Marco Campisi, Patrick H Lizotte, Matthew A Booker, Ismail Ozgenc, Moataz Noureddine, Brittany Meisenheimer, Minyue Chen, Brandon Piel, Nathaniel Spicer, Bonje N Obua, Cameron M Messier, Erin Shannon, Navin R Mahadevan, Tetsuo Tani, Pieter J Schol, Anna M Lee-Hassett, Ari Zlota, Ha V Vo, Minh Ha, Arrien A Bertram, Saemi Han, Tran C Thai, Corinne E Gustafson, Kartika Venugopal, Timothy J Haggerty, Thomas P Albertson, Antja-Voy Hartley, Pınar Özden Eser, Ze-Hua Li, Israel Cañadas, Marina Vivero, Assunta De Rienzo, William G Richards, Adnan O Abu-Yousif, Vicky A Appleman, Richard C Gregory, Alexander Parent, Neil Lineberry, Eric L Smith, Pasi A Janne, Juan J Miret, Michael Yevgeniy Tolstorukov, Rizwan Romee, Cloud P Paweletz, Raphael Bueno, David A Barbie
Activation of Tumor-Cell STING Primes NK-Cell Therapy. Cancer immunology research 10 (8) (2022)
Tyler S Beyett, Ciric To, David E Heppner, Jaimin K Rana, Anna M Schmoker, Jaebong Jang, Dries J H De Clercq, Gabriel Gomez, David A Scott, Nathanael S Gray, Pasi A Janne, Michael J Eck
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nature communications 13 (1) (2022)
Mizuki Nishino, Junwei Lu, Takuya Hino, Natalie I Vokes, Pasi A Janne, Hiroto Hatabu, Bruce E Johnson
Tumor Growth Rate After Nadir Is Associated With Survival in Patients With EGFR -Mutant Non-Small-Cell Lung Cancer Treated With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. JCO precision oncology 5 (2022)
Sai-Hong Ignatius Ou, Pasi A Janne, Ticiana A Leal, Igor I Rybkin, Joshua K Sabari, Minal A Barve, Lyudmila Bazhenova, Melissa Lynne Johnson, Karen L Velastegui, Cornelius Cilliers, James G Christensen, Xiaohong Yan, Richard C Chao, Kyriakos P Papadopoulos
First-in-Human Phase I/IB Dose-Finding Study of Adagrasib (MRTX849) in Patients With Advanced KRAS G12C Solid Tumors (KRYSTAL-1). Journal of clinical oncology : official journal of the American Society of Clinical Oncology 40 (23) (2022)
Yoshihisa Kobayashi, Geoffrey R Oxnard, Elizabeth F Cohen, Navin R Mahadevan, Joao V Alessi, Yin Pun Hung, Arrien A Bertram, David E Heppner, Maurício Fernando Silva Almeida Ribeiro, Karina P Sacardo, Rodrigo Saddi, Mariana Petaccia de Macedo, Rafael B Blasco, Jiaqi Li, Kari J Kurppa, Tom Nguyen, Emma Voligny, Guruprasad Ananda, Roberto Chiarle, Artur Katz, Michael Y Tolstorukov, Lynette M Sholl, Pasi A Janne
Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors. Nature communications 13 (1) (2022)
Michael L Cheng, Jessica K Lee, Rachit Kumar, Harry Klein, Kira Raskina, Alexa B Schrock, Kesi S Michael, Tali Mazor, Ethan Cerami, Geoffrey R Oxnard, David R Liu, Himisha Beltran, Lynette M Sholl, Mizuki Nishino, Pasi A Janne
Response to MEK Inhibitor Therapy in MAP2K1 ( MEK1 ) K57N Non-Small-Cell Lung Cancer and Genomic Landscape of MAP2K1 Mutations in Non-Small-Cell Lung Cancer. JCO precision oncology 6 (2022)
Philip Cohen, Darren Ae Cross, Pasi A Janne
Kinase drug discovery 20 years after imatinib: progress and future directions. Nature reviews. Drug discovery 20 (7) (2021)
Jens Köhler, Pasi A Janne
Amivantamab: Treating EGFR Exon 20-Mutant Cancers With Bispecific Antibody-Mediated Receptor Degradation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 39 (30) (2021)
Pasi A Janne, Christina Baik, Wu-Chou Su, Melissa L Johnson, Hidetoshi Hayashi, Makoto Nishio, Dong Wan Kim, Marianna Koczywas, Kathryn A Gold, Conor E Steuer, Haruyasu Murakami, James Chih-Hsin Yang, Sang-We Kim, Michele Vigliotti, Rong Shi, Zhenhao Qi, Yang Qiu, Lihui Zhao, David Sternberg, Channing Yu, Helena A Yu
Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor-Resistant, EGFR-Mutated Non-Small Cell Lung Cancer. Cancer discovery (2021)
Heidi M Haikala, Timothy Lopez, Jens Köhler, Pınar Özden Eser, Man Xu, Qing Zeng, Tyler J Teceno, Kenneth Ngo, Yutong Zhao, Elena V Ivanova, Arrien A Bertram, Brittaney A Leeper, Emily S Chambers, Anika E Adeni, Luke J Taus, Mari Kuraguchi, Paul T Kirschmeier, Channing Yu, Yoshinobu Shiose, Yasuki Kamai, Yang Qiu, Cloud P Paweletz, Prafulla C Gokhale, Pasi A Janne
EGFR inhibition enhances the cellular uptake and antitumor-activity of the HER3 antibody drug conjugate HER3-DXd. Cancer research (2021)
Venkatesh P Mysore, Zhi-Wei Zhou, Chiara Ambrogio, Lianbo Li, Jonas N Kapp, Chunya Lu, Qi Wang, Maxwell R Tucker, Jeffrey J Okoro, Gabriela Nagy-Davidescu, Xiao-Chen Bai, Andreas Plückthun, Pasi A Janne, Kenneth D Westover, Yibing Shan, David E Shaw
A structural model of a Ras-Raf signalosome. Nature structural & molecular biology 28 (10) (2021)
Pınar Özden Eser, Raymond M Paranal, Jieun Son, Elena Ivanova, Yanan Kuang, Heidi M Haikala, Ciric To, Jeffrey J Okoro, Kshiti H Dholakia, Jihyun Choi, Yoonji Eum, Atsuko Ogino, Pavlos Missios, Dalia Ercan, Man Xu, Michael J Poitras, Stephen Wang, Kenneth H Ngo, Michael Dills, Masahiko Yanagita, Timothy Lopez, Mika Lin, Jeanelle Tsai, Nicolas Floch, Emily S Chambers, Jennifer Heng, Rana Anjum, Alison D Santucci, Kesi S Michael, Alwin G Schuller, Darren Ae Cross, Paul D Smith, Geoffrey R Oxnard, David A Barbie, Lynette M Sholl, Magda Bahcall, Sangeetha Palakurthi, Prafulla C Gokhale, Cloud P Paweletz, George Q Daley, Pasi A Janne
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer. Science translational medicine 13 (609) (2021)
Magda Bahcall, Cloud P Paweletz, Yanan Kuang, Luke J Taus, Taebo Sim, Nam Doo Kim, Kshiti H Dholakia, Christie J Lau, Prafulla C Gokhale, Pratik R Chopade, Fangxin Hong, Zihan Wei, Jens Köhler, Paul T Kirschmeier, Jiannan Guo, Sujuan Guo, Stephen Wang, Pasi A Janne
Combination of type I and type II MET tyrosine kinase inhibitors as therapeutic approach to prevent resistance. Molecular cancer therapeutics (2021)
Atsuko Ogino, Jihyun Choi, Mika Lin, Margaret K Wilkens, Antonio Calles, Man Xu, Anika E Adeni, Emily S Chambers, Marzia Capelletti, Mohit Butaney, Nathanael S Gray, Prafulla C Gokhale, Sangeetha Palakurthi, Paul Kirschmeier, Geoffrey R Oxnard, Lynette M Sholl, Pasi A Janne
Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations. Molecular oncology 15 (1) (2020)
Arezou A Ghazani, Nelly M Oliver, Joseph P St Pierre, Andrea Garofalo, Irene R Rainville, Elaine Hiller, Daniel J Treacy, Vanesa Rojas-Rudilla, Sam Wood, Elizabeth F Bair, Michael Parello, Franklin Huang, Marios Giannakis, Frederick H Wilson, Elizabeth H Stover, Steven M Corsello, Tom Nguyen, Huma Q Rana, Alanna J Church, Carol Lowenstein, Carrie Cibulskis, Ali Amin-Mansour, Jennifer Heng, Lauren Brais, Abigail Santos, Patrick Bauer, Amanda Waldron, Peter Lo, Megan Gorman, Christine A Lydon, Marisa Welch, Philip McNamara, Stacey Gabriel, Lynette M Sholl, Neal I Lindeman, Judy E Garber, Barbara Koenig, Eliezer M Van Allen, Stacy W Gray, Pasi A Janne, Levi A Garraway, Nikhil Wagle
Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study. Genetics in medicine : official journal of the American College of Medical Genetics 19 (7) (2017)