The co-activator-associated arginine methyltransferase 1 (CARM1) gene is overexpressed in type 2 diabetes.
Massimo PortaCristina AmioneFederica BaruttaPaolo FornengoStefano MerloGabriella GrudenLuigi AlbanoMarco CiccarelliPaola UngaroMarilena DurazzoFrancesco BeguinotPaola BerchiallaFranco CavalloMarina TrentoPublished in: Endocrine (2018)
Increased CARM1 expression in type 2 diabetes suggests that epigenetic mechanisms are altered in human diabetes. The impact of lifestyle and pharmacological treatment on regulation of this enzyme should be further investigated.
Keyphrases
- type diabetes
- glycemic control
- cardiovascular disease
- endothelial cells
- poor prognosis
- nitric oxide
- insulin resistance
- gene expression
- weight loss
- dna methylation
- physical activity
- induced pluripotent stem cells
- nuclear factor
- adipose tissue
- immune response
- amino acid
- combination therapy
- high resolution
- replacement therapy
- high speed
- smoking cessation