Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells.
Wen-Hung WangKuo-Yu HsuanLing-Ya ChuChia-Ying LeeYu-Chang TyanZong-Shiow ChenWan-Chi TsaiPublished in: Evidence-based complementary and alternative medicine : eCAM (2017)
Researchers have reported significant effects from Danshen (Salvia miltiorrhiza) in terms of inhibiting tumor cell proliferation and promoting apoptosis in breast cancer, hepatocellular carcinomas, promyelocytic leukemia, and clear cell ovary carcinomas. Here we report our data indicating that Danshen extracts, especially alcohol extract, significantly inhibited the proliferation of the human oral squamous carcinoma (OSCC) cell lines HSC-3 and OC-2. We also observed that Danshen alcohol extract activated the caspase-3 apoptosis executor by impeding members of the inhibitor of apoptosis (IAP) family, but not by regulating the Bcl-2-triggered mitochondrial pathway in OSCC cells. Our data also indicate that the extract exerted promising effects in vivo, with HSC-3 tumor xenograft growth being suppressed by 40% and 69% following treatment with Danshen alcohol extract at 50 and 100 mg/kg, respectively, for 34 days. Combined, our results indicate appreciable anticancer activity and significant potential for Danshen alcohol extract as a natural antioxidant and herbal human oral cancer chemopreventive drug.
Keyphrases
- oxidative stress
- induced apoptosis
- cell cycle arrest
- anti inflammatory
- cell death
- high grade
- endoplasmic reticulum stress
- cell proliferation
- endothelial cells
- alcohol consumption
- electronic health record
- emergency department
- bone marrow
- pi k akt
- pluripotent stem cells
- risk assessment
- machine learning
- big data
- climate change
- drug induced
- human health