The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Jace Jones-TabahKathy HeKonstantin SenkevichNathan KarpilovskyGhislaine DeyabYuting CousineauDaria NikanorovaTaylor GoldsmithEsther Del-Cid PelliteroCarol Xq ChenWen LuoZhipeng YouNarges AbdianIsabella PietrantonioThomas GoiranJamil AhmadJennifer A RuskeyFarnaz AsayeshDan SpiegelmanCheryl WatersOury MonchiYves DauvilliersNicolas DupreIrina MiliukhinaAlla TimofeevaAnton EmelyanovSofya PchelinaLior GreenbaumSharon HassinBaerRoy N AlcalayAusten MilnerwoodThomas M DurcanZiv Gan-OrEdward A FonPublished in: Research square (2024)
The results of our genetic and functional studies indicate that the reduction of catB function negatively impacts lysosomal pathways associated with PD pathogenesis, while conversely catB activation could promote the clearance of pathogenic alpha-synuclein.