Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis.
Priscilla P OomenMarieke J H BegemannBodyl A BrandLieuwe de HaanWim VelingSanne KoopsJim van OsFilip SmitP Roberto BakkerNico van BeverenNynke BoonstraSinan GülöksüzMartijn KikkertJoran LokkerbolMachteld MarcelisBram-Sieben RosemaFranciska de BeerShiral S GangadinChris N W GeraetsErna van 't HagYudith HavemanInge van der HeijdenAlban E VoppelElske WillemseTherese van AmelsvoortMaarten BakAlbert BatallaAgaath BeenMarinte van den BoschTruus van den BrinkGunnar FaberKoen P GrootensMartin de JongeRikus KnegteringJörg KurkampAmrita MahabirGerdina H M PijnenborgTonnie StaringNatalie VeenSelene VeermanSybren WiersmaEllen GravelandJoelle HoornaarIris E C SommerPublished in: Psychological medicine (2021)
Current results demonstrate the existence of three distinct cognitive subgroups, corresponding with clinical outcome at baseline, 6- and 12-month follow-up. Importantly, the cognitively preserved subgroup was larger than the severely impaired group. Early identification of discrete cognitive profiles can offer valuable information about the clinical outcome but may not be relevant in predicting self-reported functional outcomes.