Chronic myeloid leukemia-derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells.
Julian SwatlerWioleta DudkaLukasz BugajskiMarta Brewinska-OlchowikEwa KozlowskaKatarzyna PiwockaPublished in: European journal of immunology (2019)
Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansion of leukemic cells outside the bone marrow, leading to blast crisis.
Keyphrases
- regulatory t cells
- chronic myeloid leukemia
- bone marrow
- transcription factor
- dendritic cells
- acute myeloid leukemia
- induced apoptosis
- poor prognosis
- cell cycle arrest
- public health
- mesenchymal stem cells
- cell death
- immune response
- oxidative stress
- signaling pathway
- binding protein
- cell proliferation
- genome wide identification