Synthetic Anion Transporters as Endoplasmic Reticulum (ER) Stress Inducers.
Adil S AslamAhmed FuwadHyunil RyuBaskar SelvarajJae-Won SongDae Won KimSun Min KimJae Wook LeeTae-Joon JeonDong-Gyu ChoPublished in: Organic letters (2019)
Cl--ion transporters (2a-2h) were synthesized based on the binding motifs of prodigiosin. Transporter 2e clearly displays Cl--ion transportation activity across both model and live cell membranes. Furthermore, 2e can disrupt Ca2+ homeostasis and increase the intracellular concentration of Ca2+ in the DLD-1 cell. This disruption can lead to Caspase-dependent apoptosis supported by CHOP expression (a marker of ER stress) and the appearance of the cleaved forms of Caspase 3 and PARP.
Keyphrases
- endoplasmic reticulum
- cell death
- induced apoptosis
- cell cycle arrest
- endoplasmic reticulum stress
- poor prognosis
- oxidative stress
- single cell
- binding protein
- diffuse large b cell lymphoma
- dna damage
- protein kinase
- cell therapy
- dna repair
- stem cells
- signaling pathway
- long non coding rna
- cell proliferation
- transcription factor