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DNA damage repair gene mutation testing and genetic counseling in men with/without prostate cancer: a systematic review.

Nigel ArmstrongRuben G W QuekSteve RyderJanine RossTitas BuksnysCarol ForbesKathleen M FoxElena Castro
Published in: Future oncology (London, England) (2020)
Background: Ongoing clinical trials are investigating PARP inhibitors to target the DNA damage repair (DDR) pathway in prostate cancer. DDR mutation screening will guide treatment strategy and assess eligibility for clinical trials. Materials & methods: This systematic review estimated the rate of DDR mutation testing or genetic counseling among men with or at risk of prostate cancer. Results: From 6856 records, one study fulfilled the inclusion criteria and described men undiagnosed with prostate cancer with a family history of BRCA1/2 mutation who received DDR mutation testing. Conclusion: With only one study included in this first systematic review of DDR mutation testing or genetic counseling in men with or at risk of prostate cancer, more research is warranted.
Keyphrases
  • prostate cancer
  • dna damage
  • systematic review
  • radical prostatectomy
  • clinical trial
  • meta analyses
  • oxidative stress
  • dna repair
  • smoking cessation
  • randomized controlled trial
  • phase ii
  • combination therapy