Calcineurin inhibitors in systemic sclerosis - a systematic literature review.
Nina N HofmannRobert A AmbühlSuzana JordanOliver DistlerPublished in: Therapeutic advances in musculoskeletal disease (2022)
In this systematic literature review, signals for potential effectiveness of CsA for skin and pulmonary fibrosis were found, but the evidence level of the identified studies was too low to allow robust conclusions. Randomized controlled double-blind trials are needed to conclude on the effectiveness of CNIs in SSc. Renal toxicity of CNIs was confirmed in this review and needs to be considered in the design of such studies.
Keyphrases
- systemic sclerosis
- double blind
- pulmonary fibrosis
- placebo controlled
- interstitial lung disease
- randomized controlled trial
- systematic review
- clinical trial
- case control
- phase iii
- phase ii
- open label
- case report
- study protocol
- oxidative stress
- wound healing
- soft tissue
- risk assessment
- rheumatoid arthritis
- oxide nanoparticles