Exploring the Bioactive Potentials of C 60 -AgNPs Nano-Composites against Malignancies and Microbial Infections.
Kunal BiswasAwdhesh Kumar MishraPradipta Ranjan RautaAbdullah Godran Al-SehemiMehboobali PanniparaAvik SettAmra BratovcicSatya Kumar AvulaTapan Kumar MohantaMuthupandian SaravananYugal Kishore MohantaPublished in: International journal of molecular sciences (2022)
At present, the potential role of the AgNPs/endo-fullerene molecule metal nano-composite has been evaluated over the biosystems in-vitro. The intra-atomic configuration of the fullerene molecule (C 60 ) has been studied in-vitro for the anti-proliferative activity of human breast adenocarcinoma (MDA-MB-231) cell lines and antimicrobial activity against a few human pathogens that have been augmented with the pristine surface plasmonic electrons and antibiotic activity of AgNPs. Furthermore, FTIR revealed the basic vibrational signatures at ~3300 cm -1 , 1023 cm -1 , 1400 cm -1 for O-H, C-O, and C-H groups, respectively, for the carbon and oxygen atoms of the C 60 molecule. NMR studies exhibited the different footprints and magnetic moments at ~7.285 ppm, explaining the unique underlying electrochemical attributes of the fullerene molecule. Such unique electronic and physico-chemical properties of the caged carbon structure raise hope for applications into the drug delivery domain. The in-vitro dose-dependent application of C 60 elicits a toxic response against both the breast adenocarcinoma cell lines and pathogenic microbes. That enables the use of AgNPs decorated C 60 endo fullerene molecules to design an effective anti-cancerous drug delivery and antimicrobial agent in the future, bringing a revolutionary change in the perspective of a treatment regime.
Keyphrases
- drug delivery
- silver nanoparticles
- endothelial cells
- solar cells
- squamous cell carcinoma
- induced pluripotent stem cells
- pluripotent stem cells
- gold nanoparticles
- staphylococcus aureus
- magnetic resonance
- reduced graphene oxide
- molecularly imprinted
- high resolution
- ionic liquid
- gene expression
- microbial community
- molecular dynamics simulations
- density functional theory
- solid state
- dna methylation
- cell proliferation
- label free
- radiation therapy
- molecular dynamics
- climate change
- replacement therapy
- mass spectrometry
- combination therapy
- pi k akt