Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia.
Toni GrönroosArtturi MäkinenSaara LaukkanenJuha MehtonenAtte NikkiläLaura OksaSamuli RouniojaYanara Marincevic-ZunigaJessica NordlundVirva PohjolainenTimo PaavonenMerja HeinäniemiOlli LohiPublished in: Scientific reports (2020)
Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.
Keyphrases
- transcription factor
- acute lymphoblastic leukemia
- poor prognosis
- gene expression
- dna binding
- stem cells
- binding protein
- cell adhesion
- genome wide identification
- long non coding rna
- liver failure
- type diabetes
- allogeneic hematopoietic stem cell transplantation
- metabolic syndrome
- hepatitis b virus
- adipose tissue
- brain injury
- extracorporeal membrane oxygenation
- respiratory failure
- acute respiratory distress syndrome
- circulating tumor cells