Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway.
Feifei HuangTianyun GaoWenqing WangLiudi WangYuanyuan XieChenxun TaiShuo LiuYi CuiBin WangPublished in: Stem cell research & therapy (2021)
bFGF-overexpressing HUCMSCs meet the requirements of clinical MSCs and improve evident therapeutic outcomes of mouse SCI treatment, which firmly supports the safety and efficacy of gene-modified MSCs for clinical application.
Keyphrases
- umbilical cord
- signaling pathway
- mesenchymal stem cells
- spinal cord injury
- neural stem cells
- pi k akt
- induced apoptosis
- epithelial mesenchymal transition
- endothelial cells
- spinal cord
- bone marrow
- neuropathic pain
- genome wide
- copy number
- induced pluripotent stem cells
- pluripotent stem cells
- combination therapy
- adipose tissue
- metabolic syndrome
- skeletal muscle
- cell proliferation
- subarachnoid hemorrhage
- insulin resistance
- brain injury
- glycemic control
- weight loss
- dna methylation