Genomic and transcriptomic characterization of heterogeneous immune subgroups of microsatellite instability-high colorectal cancers.

Jung Ho KimMi-Kyoung SeoJi Ae LeeSeung-Yeon YooHyeon Jeong OhHyundeok KangNam-Yun ChoJeong Mo BaeGyeong Hoon KangSangwoo Kim

Published in: Journal for immunotherapy of cancer (2022)

mutations, and Wnt/Notch activation, and can be further divided into distinct gene expression subtypes, including CMS4-like CMS1 and CMS3. Our data provide novel insights into precise immunotherapeutic strategies for subtypes of MSI-H tumors.

Keyphrases

gene expression
cell proliferation
dna methylation
stem cells
big data
copy number
rna seq
machine learning
data analysis