A single-blind, randomized, crossover study on the efficacy of icatibant for sweating-induced dermal pain (icatibant for sweating-induced dermal pain).
Shunsuke TakahagiMichihiro HideYumi AoyamaAtsushi FukunagaHiroyuki MurotaPublished in: Medicine (2023)
The effectiveness of icatibant against sweating-induced dermal pain would provide clear evidence for the involvement of the bradykinin-bradykinin B2 receptor pathway in the pathogenesis of this condition. This finding may contribute to a better understanding of the underlying mechanisms of dermal pain associated with sweating stimuli and has the potential to improve patients' quality of life by suggesting potential treatment options, specifically, using drugs that inhibit bradykinin or suppress its production.
Keyphrases
- chronic pain
- pain management
- high glucose
- neuropathic pain
- diabetic rats
- end stage renal disease
- drug induced
- randomized controlled trial
- chronic kidney disease
- ejection fraction
- systematic review
- newly diagnosed
- open label
- endothelial cells
- peritoneal dialysis
- risk assessment
- postoperative pain
- patient reported outcomes
- placebo controlled
- climate change
- study protocol