Evaluation of Real-World Tumor Response Derived From Electronic Health Record Data Sources: A Feasibility Analysis in Patients With Metastatic Non-Small Cell Lung Cancer Treated With Chemotherapy.
Brittany Avin McKelveyElizabeth Garrett-MayerDonna R RiveraAmy AlabasterHillary S AndrewsElizabeth G BondThomas D BrownAmanda BrunoLauren DamatoJanet L EspiritoLaura L FernandesEric HansenPaul KluetzXinran MaAndrea McCrackenPallavi S Mishra-KalyaniYanina NatanzonDanielle PotterNicholas J RobertLawrence SchwartzRegina SchwindConnor SweetnamJoseph WagnerMark D StewartJeff D AllenPublished in: JCO clinical cancer informatics (2024)
This collaborative effort demonstrated the feasibility of aligning disparate data sources to evaluate rw-response end points using clinician-documented responses in patients with mNSCLC. Heterogeneity exists in the availability of data components to assess response and related rw-end points, and further work is needed to inform drug effectiveness evaluation within RWD sources.