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Pan-cancer single-cell landscape of tumor-infiltrating T cells.

Liangtao ZhengShishang QinWen SiAnqiang WangBaocai XingRanran GaoXianwen RenLi WangXiaojiang WuJi ZhangNan WuNing ZhangHong ZhengHanqiang OuyangKeyuan ChenZhaode BuXueda HuJia Fu JiYuanyuan Zhang
Published in: Science (New York, N.Y.) (2021)
T cells play a central role in cancer immunotherapy, but we lack systematic comparison of the heterogeneity and dynamics of tumor-infiltrating T cells across cancer types. We built a single-cell RNA-sequencing pan-cancer atlas of T cells for 316 donors across 21 cancer types and revealed distinct T cell composition patterns. We found multiple state-transition paths in the exhaustion of CD8 + T cells and the preference of those paths among different tumor types. Certain T cell populations showed specific correlation with patient properties such as mutation burden, shedding light on the possible determinants of the tumor microenvironment. T cell compositions within tumors alone could classify cancer patients into groups with clinical trait specificity, providing new insights into T cell immunity and precision immunotherapy targeting T cells.
Keyphrases
  • single cell
  • papillary thyroid
  • rna seq
  • squamous cell
  • high throughput
  • lymph node metastasis
  • squamous cell carcinoma
  • childhood cancer
  • case report
  • dna methylation
  • genome wide