Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer: a randomized controlled trial (PAM study).
E W KoevoetsS B SchagenM B de RuiterM I GeerlingsL WitloxE van der WallM M StuiverG S SonkeM J VelthuisJ J JobsenM B E Menke-PluijmersE GökerC C van der PolM E M M BosL W TickN A van HolsteijnJ van der PalenA M MayEvelyn M Monninkhofnull nullPublished in: Breast cancer research : BCR (2022)
A 6-month exercise intervention improved self-reported cognitive functioning, physical fitness, fatigue, QoL, and depression in chemotherapy-exposed breast cancer patients with cognitive problems. Tested cognitive functioning was not affected. However, subgroup analysis indicated a positive effect of exercise on tested cognitive functioning in highly fatigued patients. Trial Registration Netherlands Trial Registry: Trial NL5924 (NTR6104). Registered 24 October 2016, https://www.trialregister.nl/trial/5924 .
Keyphrases
- phase iii
- study protocol
- phase ii
- clinical trial
- randomized controlled trial
- end stage renal disease
- physical activity
- high intensity
- mental health
- open label
- chronic kidney disease
- ejection fraction
- depressive symptoms
- squamous cell carcinoma
- radiation therapy
- patient reported outcomes
- body composition
- double blind