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Cytoplasmic-delivery of polyinosine-polycytidylic acid inhibits pancreatic cancer progression increasing survival by activating Stat1-CCL2-mediated immunity.

Praveen BhoopathiAmit KumarAnjan K PradhanSantanu MajiPadmanabhan MannangattiJolene J WindleMark A SublerDongyu ZhangVignesh VudathaJose G TrevinoEsha MadanAzeddine AtfiDevanand SarkarRajan GognaSwadesh K DasLuni EmdadPaul B Fisher
Published in: Journal for immunotherapy of cancer (2023)
treatment is non-toxic toward normal pancreatic cells while displaying strong cytotoxic and potent immune activating activities in PDAC, making it an attractive therapeutic when used alone or in conjunction with SOC therapeutic agents, potentially providing a safe and effective treatment protocol with translational potential for the effective therapy of PDAC.
Keyphrases
  • signaling pathway
  • randomized controlled trial
  • cell proliferation
  • cell death
  • cell cycle arrest
  • anti inflammatory
  • bone marrow
  • liver fibrosis