Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders.
Amir Mohammad Nezhad SalariZahra RasoulizadehArezoo Gowhari ShabgahRoghayyeh Vakili-GhartavolGhasem SargaziJamshid Gholizadeh NavashenaqPublished in: Cell biochemistry and function (2024)
Kaempferol, a flavonoid compound found in various fruits, vegetables, and medicinal plants, has garnered increasing attention due to its potential neuroprotective effects in neurological diseases. This research examines the existing literature concerning the involvement of kaempferol in neurological diseases, including stroke, Parkinson's disease, Alzheimer's disease, neuroblastoma/glioblastoma, spinal cord injury, neuropathic pain, and epilepsy. Numerous in vitro and in vivo investigations have illustrated that kaempferol possesses antioxidant, anti-inflammatory, and antiapoptotic properties, contributing to its neuroprotective effects. Kaempferol has been shown to modulate key signaling pathways involved in neurodegeneration and neuroinflammation, such as the PI3K/Akt, MAPK/ERK, and NF-κB pathways. Moreover, kaempferol exhibits potential therapeutic benefits by enhancing neuronal survival, attenuating oxidative stress, enhancing mitochondrial calcium channel activity, reducing neuroinflammation, promoting neurogenesis, and improving cognitive function. The evidence suggests that kaempferol holds promise as a natural compound for the prevention and treatment of neurological diseases. Further research is warranted to elucidate the underlying mechanisms of action, optimize dosage regimens, and evaluate the safety and efficacy of this intervention in human clinical trials, thereby contributing to the advancement of scientific knowledge in this field.
Keyphrases
- cerebral ischemia
- oxidative stress
- signaling pathway
- neuropathic pain
- spinal cord injury
- subarachnoid hemorrhage
- anti inflammatory
- pi k akt
- spinal cord
- clinical trial
- brain injury
- blood brain barrier
- lps induced
- randomized controlled trial
- endothelial cells
- traumatic brain injury
- cell proliferation
- systematic review
- dna damage
- induced apoptosis
- lipopolysaccharide induced
- cognitive impairment
- atrial fibrillation
- inflammatory response
- ischemia reperfusion injury
- diabetic rats
- cognitive decline
- health risk
- climate change
- study protocol
- combination therapy
- induced pluripotent stem cells
- heat stress