LSD1 inhibitors disrupt the GFI1 transcription repressor complex.

Alba Maiques-DiazJames T LynchGary J SpencerTim C P Somervaille

Published in: Molecular & cellular oncology (2018)

Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.

Keyphrases

growth factor
drug induced
liver injury
acute myeloid leukemia
genome wide
transcription factor
single cell
allogeneic hematopoietic stem cell transplantation
adverse drug
case control
genome wide identification
bioinformatics analysis
acute lymphoblastic leukemia