Tim C P Somervaille (Tim Cp Somervaille)

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 12

Top Topics

Histone Deacetylase

Dna Methylation

Allogeneic Hematopoietic Stem Cell Transplantation

Top Venues

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Molecular & cellular oncology

This page only lists publications with an associated author ORCID identifier.

Publications

Lucy Ginn, Joe Maltas, Martin J Baker, Anshuman Chaturvedi, Leah Wilson, Ryan Guilbert, Fabio M R Amaral, Lynsey Priest, Holly Mole, Fiona Blackhall, Zoi Diamantopoulou, Tim C P Somervaille, Adam F L Hurlstone, Angeliki Malliri
A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells. Proceedings of the National Academy of Sciences of the United States of America 120 (40) (2023)
John O Mascarenhas, Marina Kremyanskaya, Andrea Patriarca, Francesca Palandri, Timothy Devos, Francesco Passamonti, Raajit K Rampal, Adam J Mead, Gabriella Hobbs, Joseph M Scandura, Moshe Talpaz, Nikki Granacher, Tim C P Somervaille, Ronald Hoffman, Marielle J Wondergem, Mohamed E Salama, Gozde Colak, Jike Cui, Jean-Jacques Kiladjian, Alessandro Maria Maria Vannucchi, Srdan Verstovsek, Natalia Curto-García, Claire N Harrison, Vikas K Gupta
MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Claire N Harrison, Jacqueline S Garcia, Tim C P Somervaille, James M Foran, Srdan Verstovsek, Catriona Jamieson, Ruben A Mesa, Ellen K Ritchie, Srinivas K Tantravahi, Pankit Vachhani, Casey L O'Connell, Rami S Komrokji, Jason Harb, Jessica E Hutti, Leanne Holes, Abdullah A Masud, Silpa Nuthalapati, Jalaja Potluri, Naveen Pemmaraju
Addition of Navitoclax to Ongoing Ruxolitinib Therapy for Patients With Myelofibrosis With Progression or Suboptimal Response: Phase II Safety and Efficacy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 40 (15) (2022)
Alba Maiques-Diaz, Luciano Nicosia, Naseer J Basma, Isabel Romero-Camarero, Francesco Camera, Gary J Spencer, Fabio M R Amaral, Fabrizio Simeoni, Bettina Wingelhofer, Andrew J K Williamson, Andrew Pierce, Anthony D Whetton, Tim C P Somervaille
HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block. Oncogene 41 (44) (2022)
Mark S Williams, Naseer J Basma, Fabio M R Amaral, Daniel H Wiseman, Tim C P Somervaille
Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity. BMC cancer 21 (1) (2021)
Fabrizio Simeoni, Tim C P Somervaille
Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia. Molecular & cellular oncology 8 (6) (2021)
Luciano Nicosia, Francesca Ludovica Boffo, Elena Ceccacci, Fabio Conforti, Isabella Pallavicini, Fabio Bedin, Roberto Ravasio, Enrico Massignani, Tim C P Somervaille, Saverio Minucci, Tiziana Bonaldi
Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML. Oncogene (2021)
Mark S Williams, Naseer J Basma, Fabio M R Amaral, Gillian Williams, John P Weightman, Wolfgang Breitwieser, Louisa Nelson, Stephen S Taylor, Daniel H Wiseman, Tim C P Somervaille
Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer. BMC cancer 20 (1) (2020)
Olga Salamero, Pau Montesinos, Christophe Willekens, José Antonio Pérez-Simón, Arnaud Pigneux, Christian Récher, Rakesh Popat, Cecilia Carpio, César Molinero, Cristina Mascaró, Joaquim Vila, M Isabel Arévalo, Tamara Maes, Carlos Buesa, Francesc Bosch, Tim C P Somervaille
First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 38 (36) (2020)
Mark S Williams, Tim C P Somervaille
Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia. Molecular & cellular oncology 7 (2) (2020)
Gauri Deb, Bettina Wingelhofer, Fabio M R Amaral, Alba Maiques-Diaz, John A Chadwick, Gary J Spencer, Emma L Williams, Hui-Sun Leong, Tamara Maes, Tim C P Somervaille
Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia. Leukemia 34 (5) (2019)
Alba Maiques-Diaz, James T Lynch, Gary J Spencer, Tim C P Somervaille
LSD1 inhibitors disrupt the GFI1 transcription repressor complex. Molecular & cellular oncology 5 (4) (2018)