Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus".

Francesco PizzarelliVincenzo CantaluppiVincenzo PanichiAlessandro ToccafondiGiuseppe FerroSerena FarruggioElena GrossiniPietro Claudio DattoloVincenzo MinielloMassimiliano MiglioriCristina GrimaldiAldo CasaniMaurizio BorzumatiStefano CusinatoAlessandro CapitaniniAlessandro QuerciaOliviero FilibertiLucia Daninull null

Published in: Journal of nephrology (2021)

Citrate buffer modulated IL-6, hsCRP and Klotho levels during high volume OL-HDF. These results are not attributable to differences in the dialysis technology that was applied and may suggest a potential biological effect of citrate on CKD-associated inflammatory state. ClinicalTrials.gov identifier NCT02863016.

Keyphrases

chronic kidney disease
double blind
end stage renal disease
open label
oxidative stress
placebo controlled
clinical trial
randomized controlled trial
phase ii
study protocol