Crush Injury and Simulated Flight Effects on Muscle Gene Expression in Female Mice.

These findings expand our understanding of the genetic changes that occur in muscle in response to a crush injury, including those related to the macrophage protein, Cd68. Nursing interventions addressing adequate functioning after crush muscle injury may need to consider the effects on Cd68 and its closely related genes. Additionally, our results suggest a responsiveness of the gene, Mid1, to flight-relevant hypobaric hypoxia. Changes in expression of Mid1 may be appropriate in assessing the long-term health of flight crew members.