DNA Methylation in the Anti-Mullerian Hormone Gene and the Risk of Disease Activity in Multiple Sclerosis.
Antonino GiordanoBéatrice PignoletElisabetta MasciaFerdinando ClarelliMelissa SorosinaKaalindi MisraFlorence BucciarelliLaura FerrèLucia MoiolaRoland LiblauMassimo FilippiFederica EspositoPublished in: Annals of neurology (2024)
This study uncovered a novel molecular pathway implicating the interaction between DNA methylation and genetic variation in the risk of disease activity in MS, emphasizing the role of sex hormones, particularly the AMH, in MS pathobiology. ANN NEUROL 2024.
Keyphrases
- disease activity
- multiple sclerosis
- dna methylation
- systemic lupus erythematosus
- rheumatoid arthritis
- genome wide
- rheumatoid arthritis patients
- ankylosing spondylitis
- mass spectrometry
- juvenile idiopathic arthritis
- gene expression
- copy number
- ms ms
- white matter
- single molecule
- neural network
- genome wide identification
- genome wide analysis