Single-cell RNA expression profiling of SARS-CoV-2-related ACE2 and TMPRSS2 in human trophectoderm and placenta.
D CuiY LiuX JiangC DingLiona Chiu Yee PoonH WangH YangPublished in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2021)
ACE2- and TMPRSS2-positive cells are present in the human TE and placenta in all three trimesters of pregnancy, which indicates the possibility that SARS-CoV-2 could spread via the placenta and cause intrauterine fetal infection. © 2020 International Society of Ultrasound in Obstetrics and Gynecology.
Keyphrases
- sars cov
- endothelial cells
- single cell
- induced pluripotent stem cells
- induced apoptosis
- angiotensin ii
- magnetic resonance imaging
- angiotensin converting enzyme
- pluripotent stem cells
- high throughput
- rna seq
- pregnant women
- gene expression
- dna methylation
- cell death
- endoplasmic reticulum stress
- pregnancy outcomes
- pi k akt