Protocol and statistical analysis plan for the PREOXI trial of preoxygenation with noninvasive ventilation vs oxygen mask.
Kevin W GibbsAdit A GindeMatthew E PrekkerKevin P SeitzSusan B StempekCaleb TaylorSheetal GandotraHeath WhiteDaniel Resnick-AultAkram KhanAmira MohmedJason C BrainardDaniel G FeinNeil R AggarwalMicah R WhitsonStephen J HallidayJohn P GaillardVeronika BlinderBrian E DriverJessica A PalakshappaBradley D LloydJoanne M WozniakMatthew C ExlineDerek W RussellShekhar GhamandeCori WithersKinsley A HubelAri MoskowitzJill BastmanLuke AndreaPeter D SottileDavid B PageMicah T LongJordan Kugler GoransonRishi MalhotraBrit J LongSteven G SchauerAndrew ConnorErin AndersonKristin MaestasJillian P RhoadsKelsey WomackBrant ImhoffDavid R JanzStacy A TrentWesley H SelfTodd W RiceMatthew W SemlerJonathan D Caseynull nullPublished in: medRxiv : the preprint server for health sciences (2023)
• Hypoxemia is common during emergency tracheal intubation• Supplemental oxygen prior to intubation (preoxygenation) reduces risk of hypoxemia• The PREOXI trial compares noninvasive ventilation vs oxygen mask preoxygenation• This protocol describes the design, methods, and planned analyses• PREOXI is the largest trial of preoxygenation for emergency intubation to date.