A Genomic Score to Predict Local Control among Patients with Brain Metastases Managed with Radiation.
Nayan LambaDaniel N CagneyPaul J CatalanoDewey KimHesham ElhalawaniDaphne A Haas-KoganPatrick Y WenNikhil WagleAyal A AizerPublished in: Neuro-oncology (2023)
We developed a genomic score to quantify local recurrence risk following brain-directed radiation. To our knowledge, this represents the first study to systematically correlate DNA-based alterations with radiotherapeutic outcomes in BrM. If validated, Brain-RPS has potential to facilitate clinical trials aimed at genome-based personalization of radiation in BrM.
Keyphrases
- brain metastases
- clinical trial
- small cell lung cancer
- resting state
- white matter
- healthcare
- copy number
- radiation induced
- cerebral ischemia
- functional connectivity
- randomized controlled trial
- type diabetes
- circulating tumor
- genome wide
- single molecule
- dna methylation
- skeletal muscle
- open label
- weight loss
- subarachnoid hemorrhage
- phase ii
- nucleic acid
- double blind
- free survival