Natural history of initially asymptomatic severe aortic stenosis: a one-stage meta-analysis.

Joshua Teik Ann Tan George Shiyao He Jolene Li Ling Chia Gladys Qiao Xuan Tan Yao Neng Teo Yao Hao Teo Nicholas Li-Xun Syn Ping Chai Raymond C C Wong Tiong-Cheng Yeo William Kok-Fai Kong Kian Keong Poh Ching-Hui Sia

Published in: Clinical research in cardiology : official journal of the German Cardiac Society (2024)

Our results reveal poor cardiovascular outcomes for patients with asymptomatic severe AS on conservative treatment. A significant proportion eventually requires an AVR. Further research is needed to determine if early intervention with AVR is more effective than conservative treatment.

Keyphrases

aortic stenosis
systematic review
randomized controlled trial
ejection fraction
early onset
aortic valve
transcatheter aortic valve implantation
left ventricular
heart failure
coronary artery disease
genome wide
meta analyses
dna methylation
combination therapy
atrial fibrillation