Complex deformation of cartilage micropellets following mechanical stimulation promotes chondrocyte gene expression.
Noémie PetitjeanPatrick CanadasChristian JorgensenPascale RoyerSimon Le Floc'hDanièle NoëlPublished in: Stem cell research & therapy (2023)
Our data demonstrate that the dynamic deformation of cartilage micropellets by fluidic-based compression modulates the expression of chondrocyte genes responsible for the production of a cartilage-like extracellular matrix. This lays the foundations for further investigating the chondrocyte mechanobiology and the cartilage growth under mechanical stimulation.