PM2.5 Induced the Expression of Fibrogenic Mediators via HMGB1-RAGE Signaling in Human Airway Epithelial Cells.
Weifeng ZouFang HeSha LiuJinding PuJinxing HuQing ShengTao ZhuTianhua ZhuBing LiPixin RanPublished in: Canadian respiratory journal (2018)
PM2.5 induces the expression of TGF-β1, PDGF-AB, and PDGF-BB in vitro via HMGB1-RAGE signaling, suggesting that this pathway may contribute to the airway remodeling observed in patients with COPD.
Keyphrases
- poor prognosis
- particulate matter
- air pollution
- endothelial cells
- chronic obstructive pulmonary disease
- smooth muscle
- heavy metals
- high glucose
- polycyclic aromatic hydrocarbons
- vascular smooth muscle cells
- binding protein
- lung function
- long non coding rna
- growth factor
- risk assessment
- drug induced
- water soluble
- cystic fibrosis
- signaling pathway
- oxidative stress
- recombinant human