Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats.
Mahtab MollashahiRazieh KooshkiSaeed Esmaeili-MahaniPublished in: Arquivos de neuro-psiquiatria (2020)
Overall, i.t. administration of ABA (10 µg/rat) induced analgesia and p-ERK down-expression likely by involving the PKA-dependent mechanism.