Tgr5-/- mice are protected from ethanol-induced metabolic alterations through enhanced leptin and Fgf21 signaling.

Sabita Pokhrel Matthew Dilts Zachary Stahl Shannon Boehme Gabrielle Frame John Y L Chiang Jessica M Ferrell

Published in: Hepatology communications (2023)

Tgr5-/- mice are protected from ethanol-induced liver damage and lipid accumulation. Alterations in lipid uptake and Fgf21 signaling, and enhanced metabolic activity of white adipose tissue, may mediate these effects.

Keyphrases

adipose tissue
high glucose
diabetic rats
high fat diet induced
insulin resistance
drug induced
fatty acid
metabolic syndrome