The association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study.
Laura S ChiuAlison PedleyJoseph M MassaroEmelia J BenjaminGary F MitchellDavid D McManusJayashri AragamRamachandran S VasanSusan ChengMichelle T LongPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Increased liver fat was associated with multiple subclinical cardiac dysfunction measures, with most of associations mediated by obesity. Interestingly, the association of liver fat and LV filling pressure was only partially mediated by BMI, suggesting a possible direct effect of liver fat on LV filling pressure. Further confirmatory studies are needed.