Human Wharton's Jelly Mesenchymal Stem Cell Secretome Modifies the Processes of Neuroprotection and Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium at Transcriptional Level.
M Hossein NowroozzadehShiva GhazanfariFatemeh Sanie-JahromiPublished in: Molecular biology reports (2023)
According to the present data, WJMSC-S can affect the EMT and neuroprotection processes at the mRNA level by suppressing EMT and promoting neuroprotection in RPE cells. This finding may have positive clinical implications in the context of RD and PVR.
Keyphrases
- epithelial mesenchymal transition
- cerebral ischemia
- brain injury
- transforming growth factor
- induced apoptosis
- signaling pathway
- mesenchymal stem cells
- endothelial cells
- umbilical cord
- cell cycle arrest
- bone marrow
- gene expression
- blood brain barrier
- endoplasmic reticulum stress
- pluripotent stem cells
- transcription factor
- electronic health record
- big data
- stem cells
- heat shock
- deep learning
- binding protein
- cell death
- artificial intelligence