Upregulation of RCAN1.4 by HIF1α alleviates OGD-induced inflammatory response in astrocytes.

Xiaxin YangYan YunPin WangJuan ZhaoXiulian Sun

Published in: Annals of clinical and translational neurology (2022)

Our results reveal a novel mechanism underscoring the upregulation of RCAN1.4 by HIF1α and the protective effect of RCAN1.4 against postischemic inflammation, suggesting its significance as a promising therapeutic target for ischemic stroke treatment.

Keyphrases

inflammatory response
poor prognosis
cell proliferation
oxidative stress
endothelial cells
high glucose
signaling pathway
diabetic rats
lipopolysaccharide induced
atrial fibrillation
genome wide
drug induced
mouse model
toll like receptor
long non coding rna
combination therapy
smoking cessation
stress induced