Abnormally activated OPN/integrin αVβ3/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer.

Yulong FuYang ZhangZhe LeiTing LiuTingting CaiAnqi WangWenwen DuYuanyuan ZengJianjie ZhuZeyi LiuJian-An Huang

Published in: Journal of hematology & oncology (2020)

OPN contributes to acquired EGFR-TKI resistance by up-regulating expression of integrin αVβ3, which activates the downstream FAK/AKT and ERK signalling pathways to promote cell proliferation in NSCLC.

Keyphrases

tyrosine kinase
small cell lung cancer
cell proliferation
epidermal growth factor receptor
advanced non small cell lung cancer
cell migration
signaling pathway
poor prognosis
pi k akt
brain metastases
cell adhesion
chronic myeloid leukemia
wild type