Unlocking the Pancreatic Cancer Puzzle: Using Intermediate Cells to Target Treatment.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

KRT17-high intermediate cell population with elevated CXCL8 expression informed elevated myeloid infiltration status in tumors and associated with protumorigenic signatures in peripheral granulocytes from patients with pancreatic cancer. Furthermore, CXCL8 plasma levels were found to resemble KRT17+/CXCL8+ abundance in tumors, in which higher levels predicted worse patient outcomes. See related article by Carpenter et al., p. 2497.

Keyphrases

induced apoptosis
poor prognosis
single cell
cell cycle arrest
bone marrow
acute myeloid leukemia
cell therapy
genome wide
stem cells
oxidative stress
cell death
gene expression
signaling pathway
immune response