Alterations in mouse visceral adipose tissue mRNA expression of islet G-protein-coupled receptor ligands in obesity.

Tanyel AshikVivian LeePatricio Atanes Shanta Jean Persaud

Published in: Diabetic medicine : a journal of the British Diabetic Association (2022)

Mouse visceral adipose tissue showed significant alterations in expression of mRNAs encoding islet GPCR ligands in obesity. Our data point to ligands of interest for future research on adipose-islet crosstalk via secreted ligands acting at islet GPCRs. Such research may identify islet GPCRs with therapeutic potential for T2D.

Keyphrases

insulin resistance
adipose tissue
high fat diet
metabolic syndrome
high fat diet induced
type diabetes
skeletal muscle
weight loss
poor prognosis
physical activity
electronic health record
body mass index
long non coding rna
current status