Computational insights into CRISP3 downregulation in cervical cancer and its cervical lineages pattern.
Ricardo Cesar CintraAndrés Galindo CéspedesMércia Patrícia Ferreira ConceiçãoMaiza Vitoria Aguiar Silva OliveiraAlessandro BuronDeisiane Rodrigues das NevesFabio Alves MoraesOlinda Maria GamarraDaniel Rodrigues de BastosPublished in: Precision clinical medicine (2024)
We identified a significant downregulation of CRISP3 in CC, particularly in cases with HPV16 infection and SCC, which was associated with poorer OS. Preliminary findings suggest that epigenetic treatments with TSA and 5-aza may modulate CRISP3 expression, warranting further research to elucidate its regulatory mechanisms and potential as a prognostic biomarker.