The polymyxin-B direct hemoperfusion OPTimal Initiation timing with Catecholamine PMX-OPTIC study: A multicenter retrospective observational study.
Kensuke NakamuraTetsuya OkazakiAkihito TampoKatsunori MochizukiNaoki KandaTakahiro OnoKunio YanagitaTaro ShimomuraTaichi MuraseKen SaitoTakahiro HirayamaTomoaki ItoKoji OgawaMizuki NakamuraTomohiro OdaTakeshi MorishimaTakuma FukushimaHiroharu YasuiNaoki AkashiKojiro OshimaHiroo KawarazakiTsukasa AkibaSusumu UemuraYuhei HonmaKenichi NittaKoji OkamotoShunsuke TakakiHirotaka TakedaChizuru YamashitaPublished in: Artificial organs (2024)
The induction of PMX-DHP at the time of the peak vasopressor dose correlated with lower mortality. PMX-DHP is one of the options available for elevating blood pressure in septic shock, and its initiation either too early or late for shock peak may not improve the outcome.