T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities.
Bodo C MelnikS M JohnW ChenG PlewigPublished in: The British journal of dermatology (2018)
HS immunopathogenesis is closely related to deviations of the Th17/Treg balance, which may negatively affect Treg-controlled HF stem cell homeostasis and infundibular integrity. Pharmacological intervention should not only attenuate Th17/IL-17 signalling, but should also improve Treg function in order to stabilize HF stem cell homeostasis and infundibular integrity.
Keyphrases
- hidradenitis suppurativa
- stem cells
- cell therapy
- randomized controlled trial
- metabolic syndrome
- insulin resistance
- type diabetes
- single cell
- multiple sclerosis
- weight gain
- smoking cessation
- dendritic cells
- transcription factor
- high fat diet induced
- body mass index
- bone marrow
- immune response
- adipose tissue
- mesenchymal stem cells