Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer.

Meera PatelKathryn A F PennelJean A QuinnHannah HoodDavid K ChangAndrew V BiankinSelma RebusAntonia K RoseweirJames Hugh ParkPaul G HorganDonald C McMillan Joanne Edwards

Published in: British journal of cancer (2022)

These results suggest the spatial expression of IKKα is a potential biomarker in colorectal cancer. This is associated with a differential mutational profile highlighting possible distinct signalling roles for IKKα in the context of colorectal cancer as well as potential implications for future treatment strategies using IKKα inhibitors.

Keyphrases

poor prognosis
binding protein
long non coding rna
single cell
risk assessment
climate change