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Transition-Metal-Free Carbon Isotope Exchange of Phenyl Acetic Acids.

Gianluca DestroKaisa HorkkaOlivier LoreauDavid-Alexandre BuissonLee KingstonAntonio Del VecchioMagnus SchouCharles S ElmoreFrédéric TaranThibault CantatDavide Audisio
Published in: Angewandte Chemie (International ed. in English) (2020)
A transition-metal-free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2 , this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [14 C] and [13 C]. A proof of concept with [11 C] was also obtained with low molar activity valuable for distribution studies.
Keyphrases
  • transition metal
  • randomized controlled trial
  • minimally invasive
  • gas chromatography
  • mass spectrometry